Title: Modulation of Hepatic Cytochrome P450s by Citrobacter rodentium Infection in Interleukin-6- and Interferon-γ-null Mice
نویسندگان
چکیده
منابع مشابه
Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune Deficient (SCID) Mice
words: 249 Introduction words: 679 Discussion words: 1,360 Abbreviations used: CR, Citrobacter rodentium; FMO, Flavin monooxygenase; IFN γ, interferon-γ; IL, interleukin; P450, cytochrome P450; RAG1, Recombination Activating Gene 1; SCID, severe combined immune deficiency; TLR, Toll-like receptor; TNFα, tumor necrosis factor-α DMD #46557 This article has not been copyedited and formatted. The f...
متن کاملHepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice.
Citrobacter rodentium is the rodent equivalent of human enteropathogenic Escherichia coli infection. This study investigated regulation of hepatic and renal cytochrome P450 (P450) mRNAs, hepatic P450 proteins, cytokines, and acute phase proteins during C. rodentium infection. Female C3H/HeOuJ (HeOu) and C3H/HeJ (HeJ) mice [which lack functional toll-like receptor 4 (TLR4)] were infected with C....
متن کاملRegulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentium.
We reported previously that infection of C3H/HeOuJ (HeOu) mice with the murine intestinal pathogen Citrobacter rodentium caused a selective modulation of hepatic cytochrome P450 (P450) gene expression in the liver that was independent of the Toll-like receptor 4. However, HeOu mice are much more sensitive to the pathogenic effects of C. rodentium infection, and the P450 down-regulation was asso...
متن کاملDmd055525 596..602
Various disease models have been shown to alter hepatic drugmetabolizing enzyme (DME) and transporter expression and to induce cholestasis through altered enzyme and transporter expression. Previously, we detailed the regulation of hepatic DMEs during infectious colitis caused by Citrobacter rodentium infection. We hypothesized that this infection would also modulate hepatic drug transporter ex...
متن کاملSelective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in severe combined immune-deficient mice.
The profile of selective modulation of hepatic cytochrome P450 (P450) gene expression caused by infection with the murine intestinal pathogen Citrobacter rodentium has been well characterized in multiple genetic backgrounds; yet, the mechanisms underlying this modulation are still not entirely understood. Although several studies have addressed the roles of cytokines from the innate immune syst...
متن کامل